Despite I would love to have them, I find the Po2 VERY slow. Would be valid, solid gameplay for solo playing, but for multiplayer, more difficult. The cruise speed of a po2 is 110 km/h Try to fly that speed: take our beloved Tante Ju with full flaps, and manage to fly at 110km/h (almost stall speed) and fly with it... takes a LOT of time actually to even do a "tiny" 50 km. (typical low objective distance in MP)
The Ju-52 is listed at 210kph,, yet ingame it is mostly flown around 230-240kph.
The Po-2 is listed at 110 Cruise and 155 Maximum, so my guess is that ingame it will be flown much faster than Civilians would have, so my guess realistically it's more like 130-140.
That's 50km in around 20 Minutes. Since you wouldn't cross the Front by much, you wouldn't have to fly far anyways. Most of the time it would be flown in your own territory, just like a 52.
The main challenges it would be used for is Bushcrafting, STOLing and all the fun connected to that. Maybe a bit of Front Line Low Level stuff as well.