German pilots in the West flying FW190A learned very early that two 20mm and two mg were more than enough against any Allied aircraft, even for bombers. This was well before the D-9 ever showed up with 2 MG151 and two heavy hitting 13mm all placed close to the center-line. A rookie pilot with JG26 asked why his FW190A didn't have the outer guns installed, he was told "you don't need them".
An MG151/20mm cannon round hitting whatever aircraft you are sitting in is very bad news. Especially if it's a mine round. I've read so many accounts of what these rounds do to humans after they penetrate a B-17 or B-24 air frame - blowing arms and legs off, decapitating etc. It's awful. It was heavy enough armament for any Allied fighter, including the P-47.
The 30mm MK-108 is another level of destruction altogether. A JG/7 pilot said aircraft hit by it would "burst like a balloon".
As for the Ta-152...it was an extreme altitude fighter, built for performance at altitudes even P-47s had trouble breathing. Up there they were obscenely fast and the long glider-like wings meant they were highly maneuverable in the thinner air up there. They were not optimized for dogfights on the deck (slow on the deck by late-war standards), yet the war situation placed the small number of them available there anyway. Ironically the huge wing made the aircraft a superb turner on the deck.